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求助统计显著性分析

我想分析在一组基因启动子中某一碱基组合出现次数是否是显著的，我又找了11组随机启动子背景序列和它对比，见图，请教怎么做统计学的显著性分析来找出哪个碱基组合在启动子中可以当做MOTIF?注：每组启动子都是160个，每组一共24万碱基，图中的数字表示在对应的一组启动子中出现该碱基组合的启动子个数...

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